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Synthesis of kojic acid derivatives as secondary binding site probes of d-amino acid oxidase |
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| Authors: | Mithun Raje Niyada Hin Bridget Duvall Dana V Ferraris James F Berry Ajit G Thomas Jesse Alt Camilo Rojas Barbara S Slusher Takashi Tsukamoto |
| Institution: | 1. Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA;2. Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| Abstract: | A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit d-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors. |
| Keywords: | Flavoenzyme Kojic acid Schizophrenia |
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