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Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV |
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| Authors: | Mark J Mitton-Fry Steven J Brickner Judith C Hamel Lori Brennan Jeffrey M Casavant Michael Chen Tao Chen Xiaoyuan Ding James Driscoll Joel Hardink Thuy Hoang Erbing Hua Michael D Huband Meghan Maloney Anthony Marfat Sandra P McCurdy Dale McLeod Michael Plotkin Christopher Zook |
| Institution: | Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA |
| Abstract: | A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed. |
| Keywords: | Antibacterial DNA gyrase Dual-targeting Inhibitor Topoisomerase IV |
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