Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa |
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| Authors: | Kwon Ki Bang Cheong-Yong Yun Chul Lee Qinghao Jin Jin Woo Lee Sang-Hun Jung Dongho Lee Mi Kyeong Lee Jin Tae Hong Youngsoo Kim Bang Yeon Hwang |
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| Institution: | 1. College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea;2. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea;3. School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea |
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| Abstract: | Two new daphnane-type diterpene esters, daphneresiniferins A (1) and B (2), along with seven known diterpenes, yuanhuacine (3), yuanhuadine (4), yuanhuahine (5), genkwadaphnin (6), genkwanine A (7), genkwanine F (8), and genkwanine H (9), were isolated from the methanol extract of the flower buds of Daphne genkwa. Their structures were elucidated on the basis of spectroscopic methods, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All the isolates were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. |
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| Keywords: | Thymelaeaceae Daphnane-type diterpene Melanogenesis inhibitor |
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