New phenstatin–fatty acid conjugates: Synthesis and evaluation |
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| Authors: | Jinhui Chen David P Brown Yi-Jun Wang Zhe-Sheng Chen |
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| Institution: | 1. Department of Chemistry, St. John’s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA;2. Department of Pharmaceutical Sciences, St. John’s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA |
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| Abstract: | New phenstatin–fatty acid conjugates have been synthesized and tested against the KB-3-1, H460, MCF-7 and HEK293 cell lines, with an increase in anti-proliferative activity being observed at the micro-molar level paralleling an increase in un-saturation in the fatty acid component. |
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| Keywords: | Conjugates Fatty acids Microtubule-binding drugs Cancer chemotherapy Drug resistance reversal |
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