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Non-benzimidazole containing inhibitors of respiratory syncytial virus |
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| Authors: | David C Pryde Thien-Duc Tran Iain Gardner Helen Bright Paul Stupple Sebastien Galan Liam Alsop Lesa Watson Donald S Middleton Satish Dayal Michelle Platts Edward J Murray Tanya Parkinson Robert Webster |
| Institution: | 1. Worldwide Medicinal Chemistry, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK;2. Pharmcokinetics, Dynamics and Metabolism, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK;3. Antiinfectives Biology, Pfizer Global R and D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK |
| Abstract: | Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat. |
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