PEG mediated synthesis and pharmacological evaluation of some fluoro substituted pyrazoline derivatives as antiinflammatory and analgesic agents |
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| Authors: | Shravan Y Jadhav Sachin P Shirame Suresh D Kulkarni Sandeep B Patil Sharad K Pasale Raghunath B Bhosale |
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| Institution: | 1. Organic Chemistry Research Laboratory, School of Chemical Sciences, Solapur University, Solapur 413255, Maharashtra, India;2. Pharmacology Department, Luqman College of Pharmacy, Gulberga 584102, Karnataka, India;3. Pharmacology Department, Appasaheb Birnale College of Pharmacy, Sangli 416416, Maharashtra, India;4. Department of Chemical Science, University of ‘Tor Vergata’, Rome, Italy |
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| Abstract: | A new series of fluoro substituted pyrazoline derivatives 5a–g and 6a–g were synthesized in good to excellent yield from the corresponding pyrazole chalcones, 4a–g, by using polyethylene glycol-400 (PEG-400) as an alternative reaction medium. The newly synthesized compounds were characterized and screened for their in vivo antiinflammatory and analgesic activity. Compounds 5g and 6g were found to be more potent than standard drug Diclofenac and six other compounds 5b, 5c, 5f, 6b, 6c and 6f showed significant antiinflammatory activity as compared to standard drug. Compounds 5c, 5d, 5e, 5f, 6c, 6d, 6e and 6f showed significant analgesic activity as compared to standard drug Aspirin. |
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| Keywords: | Pyrazolines PEG-400 Antiinflammatory activity Analgesic activity |
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