Development of a long acting human growth hormone analog suitable for once a week dosing |
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| Authors: | Moorthy SS Palanki Abhijit Bhat Ben Bolanos Florence Brunel Joselyn Del Rosario Danielle Dettling Mark Horn Rodney Lappe Ryan Preston Annette Sievers Nebojsa Stankovic Gary Woodnut Gang Chen |
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| Institution: | CovX, Pfizer Worldwide Research and Development, 9381 Judicial Drive, Suite 200, San Diego, CA 92121, USA |
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| Abstract: | Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine located on the Fab arm of the antibody. The resulting CovX body showed reduced affinity towards human growth hormone receptor, reduced cell-based activity, but improved pharmacodynamic properties. We have demonstrated that this CovX-body, given once a week, showed comparable activity as growth hormone given daily in an in vivo hypophysectomized rat model. |
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