Synthesis,crystal structure and antibacterial activity of new highly functionalized ionic compounds based on the imidazole nucleus |
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| Authors: | Mebarek Bahnous Abdelmalek Bouraiou Meryem Chelghoum Sofiane Bouacida Thierry Roisnel Farida Smati Chafia Bentchouala Philippe C. Gros Ali Belfaitah |
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| Affiliation: | 1. Laboratoire des Produits Naturels d’Origine Végétale et de Synthèse Organique, Université Mentouri-Constantine, Constantine 25000, Algeria;2. Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale, Université Mentouri-Constantine, Constantine 25000, Algeria;3. Centre de Diffractométrie X, UMR 6226 CNRS Unité Sciences Chimiques de Rennes, Université de Rennes I, 35042 Rennes CEDEX, France;4. Laboratoire de Microbiologie, Centre Hospitalier Universitaire Dr. Ben Badis de Constantine, Constantine 25000, Algeria;5. Groupe SOR, UMR CNRS 7565 (SRSMC), Université de Lorraine, Boulevard des aiguillettes, 54506 Vandoeuvre-Lès-Nancy, France |
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| Abstract: | Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds. |
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