Probing functional diversity in pactamycin toward antibiotic,antitumor, and antiprotozoal activity |
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Authors: | Stephen Hanessian Ramkrishna Reddy Vakiti Amit Kumar Chattopadhyay Stéphane Dorich Christian Lavallée |
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Institution: | 1. Department of Chemistry, Université de Montréal, Station Centre Ville, C.P. 6128, Montréal, Qc, Canada H3C 3J7;2. Hôpital Maisonneuve-Rosemont, 5415 boul l’Assomption, Montréal, Qc, Canada H1T 2M4 |
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Abstract: | A total of eight new analogs of pactamycin were prepared and tested alongside pactamycin and three of its natural congeners for antibacterial, anticancer, and antiprotozoal activities. The present study highlights the effects of changing the urea and aniline groups especially with regard to anticancer and antiprotozoal activities. |
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