Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract |
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| Authors: | Gary V Martinez Suryakiran Navath Kamini Sewda Venkataramanarao Rao Parastou Foroutan Ramesh Alleti Valerie E Moberg Ali M Ahad Domenico Coppola Mark C Lloyd Robert J Gillies David L Morse Eugene A Mash |
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| Institution: | 1. Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, United States;2. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, United States;3. Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, United States;4. Analytic Microscopy Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, United States |
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| Abstract: | A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd–DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47 h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated. |
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