|
|||||
|
|
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor |
|
| Authors: | Gopal Pathuri Jessica E. Thorpe Bryan C. Disch Lora C. Bailey-Downs Michael A. Ihnat Hariprasad Gali |
| Affiliation: | 1. Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Room 301, Oklahoma City, OK 73117, USA;2. Experimental Therapeutics Program, Peggy and Charles Stephenson Oklahoma Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA |
| Abstract: | Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth. |
| Keywords: | Aminopeptidase N APN CD13 Probestin Tumor angiogenesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |