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Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55 |
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| Authors: | Xiang Li Rostyslav Zvanych Jonathon Torchia Nathan A. Magarvey |
| Affiliation: | Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada;Department of Chemistry and Chemical Biology, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada |
| Abstract: | Two novel depsipeptides (1–2) were isolated from Streptomyces sp. ML55 together with two known analogues (3–4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line. |
| Keywords: | Depsipeptide Biosynthesis GRP-78 |
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