Inhibitory effect on NO production of triterpenes from the fruiting bodies of Ganoderma lucidum |
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| Authors: | Nguyen The Tung To Dao Cuong Tran Manh Hung Jeong Hyung Lee Mi Hee Woo Jae Sue Choi Jaewang Kim Sung Ho Ryu Byung Sun Min |
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| Affiliation: | 1. College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea;2. College of Natural Science, Kangwon National University, Kangweon 200-701, Republic of Korea;3. Pukyoung National University, Busan 608-737, Republic of Korea;4. Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea |
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| Abstract: | Four new lanostane triterpenes, butyl lucidenate P (1), butyl lucidenate D2 (2), butyl lucidenate E2 (3) and butyl lucidenate Q (4) along with 11 known compounds (5–15) were isolated from the fruiting bodies of Ganoderma lucidum. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Compounds 1, 3, 4, 9, 10 and 15 showed inhibitory potency with IC50 values of 7.4, 6.4, 4.3, 9.4, 9.2 and 4.5 μM, respectively. Compounds 1, 3 and 15 dose-dependently reduced the LPS-induced iNOS expressions. Preincubation of cell with 1, 3 and 15 significantly suppressed LPS-induced expression of COX-2 protein. |
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