Synthesis and micellar mimic properties of bile acid trimers |
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| Authors: | Jinrong Lu Chulong Liu Jun Hu Yong Ju |
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| Affiliation: | 1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
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| Abstract: | Two fan-shaped bile acid trimers have been synthesized via CuI-catalyzed azide–alkyne cycloaddition (CuAAC) ‘click chemistry’, and their extraction experiments of cresol red sodium (CR) and pyrene were investigated in the polar and non-polar solvents, respectively. The transmission electron microscopy (TEM) results showed that the homogenous hollow capsules formed with the diameter size range of 40–70 nm in a solution of water and acetone. Thus the amphiphilicity of fan-shaped bile acid trimers might be used as the promising candidate in biological and drug delivery applications. |
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