New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia |
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| Authors: | Bei Jiang Wen-Jing Wang Man-Ping Li Xiao-Jun Huang Feng Huang Hao Gao Ping-Hua Sun Ming-Fang He Zheng-Jin Jiang Xiao-Qi Zhang Wen-Cai Ye |
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| Institution: | 1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China;2. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, No. 601 West Huangpu Avenue, Guangzhou 510632, PR China;3. Sino-American Cancer Center, School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 210009, PR China |
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| Abstract: | The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1–3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells. |
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| Keywords: | Zingiberaceae Noreudesmane sesquiterpenoid Microglia Neuroprotection |
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