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NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry
Authors:Seham Ebrahim  Tomoki Fujita  Bryan A Millis  Elliott Kozin  Xuefei Ma  Sachiyo Kawamoto  Michelle A Baird  Michael Davidson  Shigenobu Yonemura  Yasuo Hisa  Mary Anne Conti  Robert S Adelstein  Hirofumi Sakaguchi  Bechara Kachar
Institution:1. Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA;2. Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan;3. Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20814, USA;4. National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA;5. Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
Abstract:
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  • Highlights? NMII within epithelial junctions assembles into a chain of muscle-like sarcomeres. ? Sarcomeres are paired across the junction to form transcellular contractile units. ? NMII isoforms show differential expression across heterotypic cell junctions. ? Coordinated sarcomere contractility modulates apical cell shape and tissue geometry
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