| Affiliation: | 1. Department of Medicinal Chemistry, L.S. Skaggs Pharmacy Institute, University of Utah, Salt Lake City, UT 84112, USA;2. Department of Anesthesiology, University of Utah, Salt Lake City, UT 84112, USA;3. Marine Science Institute, University of the Philippines, Diliman, Quezon City 1101, Philippines;4. Department of Biology, University of Utah, Salt Lake City, UT 84112, USA;5. Department of Malacology, Academy of Natural Sciences, Drexel University, Philadelphia, PA 19103, USA;6. Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health & Science University, Beaverton, OR 97006, USA |
| Abstract: | The bacterium Gordonia sp. 647 W.R.1a.05 was cultivated from the venom duct of the cone snail, Conus circumcisus. The Gordonia sp. organic extract modulated the action potential of mouse dorsal root ganglion neurons. Assay-guided fractionation led to the identification of the new compound circumcin A (1) and 11 known analogs (2–12). Two of these compounds, kurasoin B (7) and soraphinol A (8), were active in a human norepinephrine transporter assay with Ki values of 2575 and 867 nM, respectively. No neuroactivity had previously been reported for compounds in this structural class. Gordonia species have been reproducibly isolated from four different cone snail species, indicating a consistent association between these organisms. |
