A naphthalocyanine based near-infrared photosensitizer: Synthesis and in vitro photodynamic activities |
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| Authors: | Liqiang Luan Lanlan Ding Weijia Zhang Jiawei Shi Xiaoqiang Yu Wei Liu |
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| Affiliation: | State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China;Institute of Crystal Materials, Shandong University, Jinan 250100, China |
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| Abstract: | A hydrophilic near-infrared (NIR) photosensitizer featuring a naphthalocyanine core and peripheral carboxylate acid groups was synthesized and characterized. Its photophysical and photochemical properties were studied and compared with phthalocyanine. Due to the extended π-conjugation, both the Q band and fluorescence emit of this naphthalocyanine bathochromically shift to NIR region. It also exhibits superior NIR photodynamic efficiency to phthalocyanine as evidenced by high efficiency in generating singlet oxygen (ΦΔ = 0.66) and in vitro phototoxicity toward Hela human cervical cancer cells. Therefore, this novel naphthalocyanine could potentially be a NIR photosensitizer for photodynamic therapy. |
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| Keywords: | Naphthalocyanine Photodynamic therapy Singlet oxygen Photosensitizer |
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