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New azole antagonists with high affinity for the P2Y1 receptor |
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| Authors: | Réjean Ruel Alexandre L’Heureux Carl Thibeault Jean-Paul Daris Alain Martel Laura A. Price Qimin Wu Ji Hua Ruth R. Wexler Robert Rehfuss Patrick Y.S. Lam |
| Affiliation: | Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543, USA |
| Abstract: | Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system which leads to thiadiazole 4c as a new antiplatelet agent. |
| Keywords: | Purinergic receptor Platelet aggregation Five-membered-ring heterocyclic urea mimics Thiadiazoles |
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