Facile regioselective synthesis of novel bioactive thiazolyl-pyrazoline derivatives via a three-component reaction and their antimicrobial activity |
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| Authors: | Bahman Sharifzadeh Nosrat O Mahmoodi Manouchehr Mamaghani Khalil Tabatabaeian Alireza Salimi Chirani Iraj Nikokar |
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| Institution: | 1. Department of Organic Chemistry, University of Guilan, PO Box 41335-1914, Rasht, Iran;2. Department of Medical Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, PO Box 19835-151, Tehran, Iran;3. Laboratory of Microbiology and Immunology of Infectious Diseases, Paramedicine Faculty, Guilan University of Medical Sciences, PO Box 44715-1361, Guilan, Iran |
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| Abstract: | A series of novel 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles have been prepared by a three-component cyclo-condensation of various chalcones, thiosemicarbazide and phenacyl bromide. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. The reaction was efficiently catalyzed in one-pot by a few drops of HCl in EtOH under reflux conditions providing the title compounds in moderate to high yields. The antibacterial activity of the selected products was examined. Some products exhibit promising activities. |
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