Anti-inflammatory norditerpenoids from the soft coral Sinularia maxima |
| |
| Authors: | Nguyen Phuong Thao Nguyen Hoai Nam Nguyen Xuan Cuong Tran Hong Quang Pham The Tung Le Duc Dat Doobyeong Chae Sohyun Kim Young-Sang Koh Phan Van Kiem Chau Van Minh Young Ho Kim |
| |
| Institution: | 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam;2. College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea;3. School of Medicine, Brain Korea 21 Program, and Institute of Medical Science, Jeju National University, Jeju 690-756, South Korea |
| |
| Abstract: | Chemical investigation of the soft coral Sinularia maxima resulted in the isolation of seven norditerpenoids, including two new compounds, 12-hydroxy-scabrolide A (2) and 13-epi-scabrolide C (6). The structures of the isolated compounds were elucidated based on extensive spectroscopic evidence including Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and both one- and two-dimensional nuclear magnetic resonance (1D and 2D NMR, respectively), in comparison with reported data. Compound 6 potently inhibited IL-12 and IL-6 production in LPS-stimulated bone marrow derived dendritic (BMDCs) with IC50 values of 5.30 ± 0.21 and 13.12 ± 0.64 μM, respectively. Compound 1 exhibited moderate inhibitory activity against IL-12 and IL-6 production with IC50 values of 23.52 ± 1.37 and 69.85 ± 4.11 μM, respectively. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
