Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN) |
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Authors: | Chunhua Ma Kang Jin Jiangying Cao Lei Zhang Xiaoguang Li Wenfang Xu |
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Institution: | Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University 44, West Culture Road, Jinan 250012, PR China |
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Abstract: | Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC50 value to 0.06 ± 0.041 μM, which could be used for further anticancer agent research. |
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