Synthesis and biological evaluation of nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide as potential antiplatelet agents |
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| Authors: | Xiaoli Wang Linna Wang Zhangjian Huang Xiao Sheng Tingting Li Hui Ji Jinyi Xu Yihua Zhang |
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| Institution: | 1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China;2. Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, PR China;3. Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China |
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| Abstract: | A series of novel nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide were designed, synthesized and evaluated as potential antiplatelet agents. Compound 10b significantly inhibited the adenosine diphosphate (ADP)-induced platelet aggregation in vitro, superior to 6-amino-3-n-butylphthalide, 3-n-butylphthalide (NBP) and ticlopidine. Meanwhile 10b released moderate levels of NO, which could be beneficial for improving cardiovascular and cerebral circulation. Furthermore, 10b had an enhanced aqueous solubility relative to NBP. These findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke. |
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