New trifluoromethyl quinolone derivatives: Synthesis and investigation of antimicrobial properties |
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Authors: | Siva S. Panda Subhash C. Jain |
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Affiliation: | Department of Chemistry, University of Delhi, Delhi 110 007, India |
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Abstract: | A series of quinolone derivatives, containing different heterocyclic amines were prepared. Synthesized compounds were evaluated for their in vitro antimicrobial activities against two Gram-positive bacteria, three Gram-negative bacteria as well as four fungi. All the derivatives showed good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. They also showed moderate to comparable activity against Aspergillus niger and Candida albicans and low to moderate antifungal activity against Aspergillus fumigatus and Aspergillus flavus. |
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Keywords: | Quinolone Trifluoromethyl Antimicrobial Lipophilicity Molar refractivity |
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