HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage |
| |
| Authors: | Seung Hun Jeong Tran My Hanh Hyoung Kyu Kim Sung Ryul Lee In-Sung Song Su Jin Noh Suhee Song Hongsuk Suh Nari Kim Byoung Doo Rhee Kyung Soo Ko Jin Han |
| |
| Institution: | 1. National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633-165 Gaegeum-dong, Busanjin-gu, Busan 614 735, Republic of Korea;2. Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, 30 Jangjeon-dong, Geumjeong-gu, Busan 609 735, Republic of Korea |
| |
| Abstract: | Resveratrol is known to exert a cardioprotective effect against hypoxia/reoxygenation (H/R) injury. HS-1793 is a novel, more stable resveratrol analog, but its cardioprotective effects were unknown. The present study aimed to test the cardioprotective effect of HS-1793 against H/R injury and investigate the role of mitochondria in Sprague Dawley rat heart damage using an ex vivo Langendorff system. HS-1793 ameliorated H/R-induced mitochondrial dysfunction by reducing mitochondrial reactive oxygen species production, improving mitochondrial oxygen consumption and suppressing mitochondrial calcium (Ca2+) overload during reperfusion. Moreover, HS-1793-treated rat heart showed reduced infarct size. Our data suggest that HS-1793 can protect cardiac against mitochondrial damage following H/R, thereby suppressing injury. |
| |
| Keywords: | Mitochondria Resveratrol analogue HS-1793 Hypoxia reoxygenation injury Cardiomyocyte |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
