Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus |
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Authors: | Kaapjoo Park Byoung Moon Lee Young Hwan Kim Taedong Han Wonhui Yi Dong Hoon Lee Hyun Ho Choi Wonee Chong Chun Ho Lee |
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Institution: | Yuhan Research Institute, 416-1, Gongse-dong, Giheung-gu, Yongin-si, Gyeonggi-do, Republic of Korea |
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Abstract: | Novel benzamide derivatives were synthesized and tested at in vitro assay by measuring fold increase of glucokinase activity at 5.0 mM glucose concentration. Among the prepared compounds, YH-GKA was found to be an active glucokinase activator with EC50 of 70 nM. YH-GKA showed similar glucose AUC reduction of 29.6% (50 mg/kg) in an OGTT study with C57BL/J6 mice compared to 29.9% for metformin (300 mg/kg). Acute treatment of the compound in C57BL/J6 and ob/ob mice elicited basal glucose lowering activity. In subchronic study with ob/ob mice, YH-GKA showed significant decrease in blood glucose levels and no adverse effects on serum lipids or body weight. In addition, YH-GKA exhibited high bioavailability and moderate elimination in preclinical species. |
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