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Design,synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists |
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| Authors: | Nafizal Hossain Svetlana Ivanova Jonas Bergare Marguérite Mensonides-Harsema Martin E Cooper |
| Institution: | 1. Department of Medicinal Chemistry, RIA Innovative Medicines, AstraZeneca R&D, Pepparedsleden 1, SE-431 83 Mölndal, Sweden;2. Department of Medicinal Chemistry, AstraZeneca R&D Lund, Scheelevägen 1, SE-221 87 Lund, Sweden |
| Abstract: | A series of CCR1 antagonists based upon spirocyclic compounds 1b and 2b were synthesised in which substituted aniline moiety was replaced with substituted benzamides. In vitro data revealed that CCR1 potency could be retained in such compounds. |
| Keywords: | CCR1 Antagonists Chemokines hERG Spirocyclic |
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