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Fertility and Germline Stem Cell Maintenance under Different Diets Requires nhr-114/HNF4 in C. elegans
Authors:Xicotencatl Gracida  Christian R Eckmann
Institution:1. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Str. 108, 01307 Dresden, Germany
Abstract:
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  • Highlights? C. elegans fertility on different diets requires nuclear receptor nhr-114 activity ? Somatic NHR-114 is necessary to maintain germline stem cells under different diets ? NHR-114 might mediate a detoxification response that preserves the germline ? Bacterial tryptophan metabolites may underlie diet-sensitive nhr-114(?) sterility
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