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Synthesis and biological evaluation of technetium-99m labeled galactose derivatives as potential asialoglycoprotein receptor probes in a hepatic fibrosis mouse model |
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| Authors: | Wen-Yi Chang Hao-Wen Kao Hsin-Ell Wang Jenn-Tzong Chen Wuu-Jyh Lin Shyh-Jen Wang Chuan-Lin Chen |
| Institution: | 1. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, 155, Sec.2, Linong St., Taipei 11217, Taiwan;2. Institute of Nuclear Energy Research, Department of Isotope Application, Taoyuan, Taiwan;3. Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan |
| Abstract: | Two galactose derivatives, a monovalent 99mTc-MAMA-MGal galactoside and a divalent 99mTc-MAMA-DGal galactoside, were synthesized and radiolabeled in high radiochemical purity (>98%). Dynamic microSPECT imaging and biodistribution study of two traces in normal and liver fibrosis mice showed that the 99mTc-MAMA-DGal revealed higher specific binding to asialoglycoprotein receptors in liver and then rapidly excreted via both hepatobiliary system and renal clearance. The results suggest that 99mTc-MAMA-DGal may be used as SPECT probes for noninvasive evaluation of asialoglycoprotein receptor-related liver dysfunction. |
| Keywords: | Galactose Asialoglycoprotein Technetium-99m SPECT Liver function |
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