A ratiometric fluorescent detection of Zn(II) in aqueous solutions using pyrene-appended histidine |
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Authors: | Ponnaboina Thirupathi Keun-Hyeung Lee |
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Institution: | Bioorganic Chemistry Laboratory, Department of Chemistry and Chemical Engineering, Inha University, 100 Inha-ro, Nam-Gu, Incheon 402-751, Republic of Korea |
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Abstract: | A fluorescent chemosensor, Py-His, based on histidine was easily synthesized in solid phase synthesis. Py-His displayed a highly sensitive ratiometric response to Zn(II) with potent binding affinity (Ka = 1.17 × 1013 M?2) in aqueous solutions. The detection limit of Py-His for Zn(II) was calculated as 80.8 nM. Moreover, Py-His distinguished Zn(II) and Hg(II) by different ratiometric response type; the chemosensor showed a more enhanced increase of excimer emission intensity to Zn(II) than Hg(II). Upon addition of Ag(I) and Cu(II), Py-His showed a turn-off response mainly due to the quenching effect of these metal ions. The binding stoichiometry (2:1 or 1:1) of Py-His to target metal ions played a critical role in the fluorescent response type (ratiometric and turn off response) to target metal ions. The role of imidazole group of Py-His for ratiometric detection of Zn(II) was proposed by pH titration experiments. |
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Keywords: | Ratiometric Pyrene Fluorescence Chemosensor Zn(II) |
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