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Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion |
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| Authors: | Barbara Richichi Giuseppina Comito Linda Cerofolini Gabriele Gabrielli Alberto Marra Lisa Moni Alice Pace Lucia Pasquato Paola Chiarugi Alessandro Dondoni Lucio Toma Cristina Nativi |
| Institution: | 1. Department of Chemistry, University of Florence, via della Lastruccia 3, 13 50019 Sesto F. no, FI, Italy;2. Department of Biochemical Science, University of Florence, Viale Morgagni, 50 50134 Florence, Italy;3. Department of Chemistry, University of Ferrara, via L. Borsari, 46 44100 Ferrara, Italy;4. Department of Chemical and Pharmaceutical Science, University of Trieste, via Giorgieri, 1 34127 Trieste, Italy;5. Department of Chemistry, University of Pavia, via Taramelli, 12 27100 Pavia, Italy |
| Abstract: | A hydrolytically stable mimetic of the tumour antigen GM3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination. |
| Keywords: | Mimetic Tumour antigen Melanoma Adhesion |
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