Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells |
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Authors: | Shiyou Li Ping Wang Guangrui Deng Wei Yuan Zushang Su |
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Affiliation: | National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962-6109, USA |
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Abstract: | Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. Our bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds. Of the six new compounds (1–6), salviniol (1) is a rare abietane diterpene with a new ferruginol-menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structures. Sixteen abietane diterpenes (1, 7–17, and 19–22) demonstrated in vitro activities against human tumor cells, and 7 and 8 showed selective cytotoxicity to tumor cells over normal cells. |
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Keywords: | Giant salvinia Abietane diterpenes Salviniol Salviniside Invasive species Cytotoxicity |
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