Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region |
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| Authors: | Kohji Seio Munefumi Tokugawa Hirosuke Tsunoda Akihiro Ohkubo Fumio Arisaka Mitsuo Sekine |
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| Institution: | Department of Life Science, Tokyo Institute of Technology, 4259 Midori-ku, Nagatsuta, Yokohama 226-8501, Japan |
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| Abstract: | The structural properties of a DNA/RNA duplex having a pyrene residue at the 5′ end of DNA and a G-rich single strand region at the 3′ end of RNA were studied in detail. Fluorescence and ultracentrifugation analyses indicated the formation of a complex containing four DNA/RNA duplexes, which required a pyrene residue, G-rich sequence, RNA-type backbone, and high salt concentration. |
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| Keywords: | G-quadruplex Pyrene excimer Sedimentation analysis |
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