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Synthesis and biological evaluation of phosphonate analogues of nevirapine |
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| Authors: | Jay Parrish Leah Tong Michael Wang Xiaowu Chen Eric B. Lansdon Carina Cannizzaro Xubin Zheng Manoj C. Desai Lianhong Xu |
| Affiliation: | Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA |
| Abstract: | A series of nevirapine-based analogues containing the phosphonate functionality were prepared and evaluated in vitro against HIV RT. The effect of the phosphonate was evaluated against the wild type and Y181C HIV replication. An in vivo PK study was performed on a select analogue. |
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