Indole–porphyrin hybrids produced by metagenomics |
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Authors: | Xiao-Long Yang Toshiyuki Wakimoto Yuya Takeshige Rui He Yoko Egami Takayoshi Awakawa Ikuro Abe |
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Institution: | 1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;2. College of Pharmaceutical Science, Hebei University, Baoding 071002, PR China |
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Abstract: | New indole–porphyrin hybrid molecules were isolated from Escherichia coli harboring metagenomic DNA from the Japanese marine sponge Discodermia calyx. The indole was appended to the reactive vinyl substituent of the harderoporphyrin chromophore, encoded by the insert DNA. Thus, the chimeric pathway between the heterologously expressed porphyrins and the endogenous indole generated new indole-conjugated chiral porphyrins in E. coli. |
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Keywords: | Metagenome Marine sponge Discodermia calyx Indole–porphyrin hybrid |
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