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Evaluation of EGFR-targeted radioimmuno-gold-nanoparticles as a theranostic agent in a tumor animal model |
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| Authors: | Hao-Wen Kao Yi-Yu Lin Chao-Cheng Chen Kwan-Hwa Chi Der-Chi Tien Chien-Chung Hsia Ming-Hsien Lin Hsin-Ell Wang |
| Institution: | 1. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Linong St., Beitou District, Taipei 112, Taiwan, ROC;2. Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC;3. Department of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan, ROC;4. Institute of Nuclear Energy Research, Taoyuan, Taiwan, ROC;5. Taipei City Hospital Zhongxiao Branch, Taipei, Taiwan, ROC |
| Abstract: | This study evaluated the tumor targeting and therapeutic efficacy of a novel theranostic agent 131I-labeled immuno-gold-nanoparticle (131I-C225-AuNPs-PEG) for high epidermal growth factor receptor (EGFR)-expressed A549 human lung cancer. Confocal microscopy demonstrated the specific uptake of C225-AuNPs-PEG in A549 cells. 131I-C225-AuNPs-PEG induced a significant reduction in cell viability, which was not observed when incubated with AuNPs-PEG and C225-AuNPs-PEG. MicroSPECT/CT imaging of tumor-bearing mice after intravenous injection of 123I-C225-AuNPs-PEG revealed significant radioactivity retention in tumor suggested that 131I-labeled C225-conjugated radioimmuno-gold-nanoparticles may provide a new approach of targeted imaging and therapy towards high EGFR-expressed cancers. |
| Keywords: | Gold nanoparticle Epidermal growth factor receptor Cetuximab SPECT |
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