Design,synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors |
| |
Authors: | Allan M. Prior Yunjeong Kim Sahani Weerasekara Meghan Moroze Kevin R. Alliston Roxanne Adeline Z. Uy William C. Groutas Kyeong-Ok Chang Duy H. Hua |
| |
Affiliation: | 1. Department of Chemistry, Kansas State University, 213 CBC Building, Manhattan, KS 66506, United States;2. Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, United States;3. Department of Chemistry, Wichita State University, Wichita, KS 67260, United States |
| |
Abstract: | A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, α-ketoamide, bisulfite adduct, and α-hydroxyphosphonate transition state mimic, was also investigated. Tripeptidyls 2 and 6 possess antiviral activities against noroviruses, human rhinovirus, severe acute respiratory syndrome coronavirus, and coronavirus 229E, suggesting a broad range of antiviral activities. |
| |
Keywords: | Viral 3C and 3C-like protease inhibitors Norovirus Human rhinovirus Severe acute respiratory syndrome coronavirus Coronavirus 229E |
本文献已被 ScienceDirect 等数据库收录! |
|