Pahangensin A and B,two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley |
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| Authors: | Yasodha Sivasothy Halijah Ibrahim Audra Shaleena Paliany Siti Aisyah Alias Khalijah Awang |
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| Institution: | 1. Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia;2. Institute of Biological Sciences, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia |
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| Abstract: | The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 μg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 μg/mL) against B. cereus. |
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| Keywords: | Zingiberaceae Bis-labdanic diterpene Labdane diterpene Pahangensin A Pahangensin B Antibacterial agent |
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