|
|||||
|
|
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors |
|
| Authors: | Arun P. Chandrasekharappa Sangamesh E. Badiger Pramod K. Dubey Sunil K. Panigrahi Sekhar Reddy V.V.V. Manukonda |
| Affiliation: | 1. Aurigene Discovery Technologies Limited, 39-40, KIADB Industrial Area, Phase II, Electronic City, Hosur Road, Bangalore 560 100, India;2. Department of Chemistry, JNTUH College of Engineering, Hyderabad 500 085, India |
| Abstract: | A series of benzoxazole compounds containing oxamic acid were synthesized and screened for the PTP1B inhibition. Compound 31d showed best biochemical potency (Ki) of 6.7 μM. Structure–activity relationship were explained with the help of molecular modeling approach. |
| Keywords: | Benzimidazole Benzoxazole Oxamic acids PTP1B Diabetes pTyr mimetics |
| 本文献已被 ScienceDirect 等数据库收录！ | |