Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives |
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| Authors: | Manochehr Shahabi Eva Schirmer Karem Shanab Theerachart Leepasert Jana Ruzicka Wolfgang Holzer Helmut Spreitzer Babette Aicher Peter Schmidt Lars Blumenstein Gilbert Müller Eckhard Günther |
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| Institution: | 1. Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;2. AeternaZentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt, Germany |
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| Abstract: | A series of indazolo4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested. |
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