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Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase |
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| Authors: | Noel A. Powell Jennifer K. Hoffman Fred L. Ciske Jeffrey T. Kohrt Sangita M. Baxi Yun-Wen Peng Min Zhong Cornel Catana Jeff Ohren Lisa A. Perrin Jeremy J. Edmunds |
| Affiliation: | Pfizer Global Research & Development, Michigan Laboratories, Ann Arbor, MI 48105, USA |
| Abstract: | Optimization of the ADME properties of a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the effects of Sky inhibition. |
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