Novel 3-hydroxy vinylboronates influence sphingolipid metabolism,cause apoptosis in Jurkat cells and prevent tumor development in nude mice |
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| Authors: | Alina Botvinik Livshits Abed Al Aziz Al Quntar Zhanna Yekhtin Morris Srebnik Arie Dagan |
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| Affiliation: | 1. Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120, Israel;2. Department of Material Engineering, Faculty of Engineering, Al Quds University, Abu Dies, East Jerusalem, Israel;3. Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital Ein Kerem, The Hebrew University of Jerusalem, 91120, Israel;4. Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University of Jerusalem, 91120, Israel |
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| Abstract: | A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingolipid metabolism. In a cancer model in nude mice the lead compound E7 prevented the development of tumor as long as the treatment period continued. Moreover, it delayed tumor growth after the treatment was finished. |
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