Enhancing nicotine vaccine immunogenicity with liposomes |
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| Authors: | Jonathan W. Lockner Sam On Ho Karen C. McCague Su Ming Chiang Thai Q. Do Gary Fujii Kim D. Janda |
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| Affiliation: | 1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA;3. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;4. The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, La Jolla, CA 92037, USA;5. Molecular Express, Inc., Rancho Dominguez, CA 90220, USA |
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| Abstract: | A major liability of existing nicotine vaccine candidates is the wide variation in anti-nicotine immune responses among clinical trial participants. In order to address this liability, significant emphasis has been directed at evaluating adjuvants and delivery systems that confer more robust potentiation of the anti-nicotine immune response. Toward that end, we have initiated work that seeks to exploit the adjuvant effect of liposomes, with or without Toll-like receptor agonist(s). The results of the murine immunization study described herein support the hypothesis that a liposomal nicotine vaccine formulation may provide a means for addressing the immunogenicity challenge. |
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