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Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series |
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| Authors: | Sreekanth Ramachandran Manoranjan Panda Kakoli Mukherjee Nilanjana Roy Choudhury Subramanyam J Tantry Chaitanya Kumar Kedari Vasanthi Ramachandran Sreevalli Sharma VK Ramya Supreeth Guptha Vasan K Sambandamurthy |
| Institution: | 1. Department of Medicinal Chemistry, AstraZeneca India Pvt. Ltd, Avishkar, Bellary Road, Hebbal, Bangalore 560024, India;2. Department of Biosciences, AstraZeneca India Pvt. Ltd, Avishkar, Bellary Road, Hebbal, Bangalore 560024, India |
| Abstract: | Imidazo1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead were generated by whole cell screening of a focused library against Mycobacterium tuberculosis. Herein, we describe the synthesis and structure activity relationship evaluation of this class of inhibitors and the optimization of physicochemical properties. These are selective inhibitors of Mycobacterium tuberculosis with no activity on either gram positive or gram negative pathogens. |
| Keywords: | Antimycobacterial activity Whole cell screening Structure activity relationship Physicochemical properties |
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