Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues |
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Authors: | Bianca C. Pérez Iva Fernandes Nuno Mateus Cátia Teixeira Paula Gomes |
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Affiliation: | 1. Centro de Investigação em Química da Universidade do Porto, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, P-4169-007 Porto, Portugal;2. CICECO, Departamento de Química, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal |
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Abstract: | Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads. |
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Keywords: | Antimalarials Antiproliferative Caco-2 Chloroquine Cinnamic acid HFF-1 MCF-7 MKN-28 |
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