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Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines |
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| Authors: | Marina Sala Adele Chimento Carmela Saturnino Isabel M. Gomez-Monterrey Simona Musella Alessia Bertamino Ciro Milite Maria Stefania Sinicropi Anna Caruso Rosa Sirianni Paolo Tortorella Ettore Novellino Pietro Campiglia Vincenzo Pezzi |
| Affiliation: | 1. Department of Pharmaceutical Science, Division of Biomedicine, University of Salerno, Fisciano, SA 84084, Italy;2. Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Arcavacata di Rende, Cosenza 87036, Italy;3. Department of Pharmaceutical and Toxicological Chemistry, University of Naples “Federico II”, Naples 8013, Italy;4. Department Pharmaco-Biological, University of Messina, 98168 Messina, Italy;5. Department Pharmaceutical Chemistry, University of Bari “Aldo Moro”, 70125 Bari, Italy |
| Abstract: | It is well known that resveratrol (RSV) displayed cancer-preventing and anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation. Aim of this work was to synthesize pharmacologically active resveratrol analogs with an enhanced structural rigidity and bioavailability. In particular, we have synthesized a library of 2,3-thiazolidin-4-one derivatives in which a thiazolidinone nucleus connects two aromatic rings. Some of these compounds showed strong inhibitory effects on breast cancer cell growth. Our results indicate that some of thiazolidin-based resveratrol derivatives may become a new potent alternative tool for the treatment of human breast cancer. |
| Keywords: | Resveratrol analogs anticancer drugs 2,3-Thiazolidin-4-one derivatives Polyphenol Breast cancer cells MCF-7 SKBR3 |
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