Polymer gene delivery vectors encapsulated in thermally sensitive bioreducible shell |
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Authors: | Emilya D. Ivanova Nadya I. Ivanova Margarita D. Apostolova Sevdalina C. Turmanova Ivaylo V. Dimitrov |
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Affiliation: | 1. Institute of Polymers, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria;2. Department of Materials Science, Prof. Assen Zlatarov University, Burgas 8010, Bulgaria;3. Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria |
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Abstract: | Stable, nanosized polyelectrolyte complexes between rationally designed thermally sensitive block copolymers and plasmid DNA (polyplexes) were formed and their in vitro transfection efficiency was tested. The polyplexes were further stabilized through encapsulation into a biodegradable polymer shell. Although reduced as compared to that of the corresponding polyplexes, the encapsulated systems still show acceptable transfection efficiency. That opens the possibility to tune the balance between the safe transport and efficient delivery of DNA into the cells. |
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Keywords: | Encapsulation Gene delivery Non-viral Polyplex Transfection |
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