Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide |
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Authors: | Zhen-Wei Wu Hai-Wei Xu Gui-Fu Dai Meng-Jiao Liu Li-Ping Zhu Jian Wu Ya-Nan Wang Feng-Juan Wu Dan Zhao Ming-Fu Gao Shan-Shan Nie Wei Han Jing-Hui Song Hong-Min Liu |
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Affiliation: | 1. Department of Biotechnology, Zhengzhou University, Zhengzhou 450001, PR China;2. New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China;3. Henan Key Laboratory of Functional Biomacromolecules, Zhengzhou University, Zhengzhou 450001, PR China |
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Abstract: | In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure–activity relationships were studied. Compared to 1, compounds 8a–8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs. |
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Keywords: | Migration Invasion Andrographolide Derivative MMP-9 |
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