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Keratocyte Fragments and Cells Utilize Competing Pathways to Move in Opposite Directions in an Electric Field
Authors:Yaohui Sun  Hao Do  Jing Gao  Ren Zhao  Min Zhao  Alex Mogilner
Institution:1. Institute for Regenerative Cures, Department of Dermatology, and Department of Ophthalmology, University of California Davis School of Medicine, Sacramento, CA 95817, USA;2. Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA, 95616, USA;3. Department of Mathematics, University of California, Davis, Davis, CA, 95616, USA;4. Center for Neuroscience, University of California, Davis, Davis, CA, 95616, USA;5. Yunnan Normal University, Kunming, Yunnan 650092, China;6. Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Abstract:
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  • Highlights? A cell fragment is the simplest motile electric-field-sensing unit ? Keratocyte cells and fragments migrate in opposite directions in an electric field ? Competition of two signal transduction pathways underlies keratocyte galvanotaxis ? Protrusive and contractile actin networks are steered by the electric field
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