首页 | 本学科首页   官方微博 | 高级检索  
     


Stereoselective synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD)
Authors:Wei Zhang  Xiangpeng Li  Ning Ding  Yingxia Li
Affiliation:Department of Medicinal Chemistry, School of Pharmacy, Fudan University, , Shanghai, 201203 China
Abstract:The stereocontrolled synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid was accomplished using a glutamate derivative as starting material. The key steps of this stereochemical synthetic pathway involved an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.
Keywords:amino acids  peptaibiotics  AHMOD  synthesis  stereoselectivity
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号