Stereoselective synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD) |
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Authors: | Wei Zhang Xiangpeng Li Ning Ding Yingxia Li |
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Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Fudan University, , Shanghai, 201203 China |
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Abstract: | The stereocontrolled synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid was accomplished using a glutamate derivative as starting material. The key steps of this stereochemical synthetic pathway involved an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd. |
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Keywords: | amino acids peptaibiotics AHMOD synthesis stereoselectivity |
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